The aim of this paper is to construct a transdisciplinary research model of the contagion. First of all, we tried to underline a polysemy and metaphoric complexity of the term of contagion. Then we attempted to present this problematics of contagion as a transdisciplinary paradigm of human and social sciences in mentioning its potential fields such as the contagion as a structuration of the social, the biopolitical dimensions of the contagion. In this regard, the immunology model by the italian philosopher Esposito to explain the nature of the modern state seems insightful. As a conclusion, we suggested a problematics of semio-anthropology of contagion in presenting some research areas such as semiotics of institutions responsible for the contagion, semiotics of the virality, and the contagiosity of the language.