In this article, I try to examine the thought of Nietzsche(1844-1900) on Desire and Culture. Nietzsche considers culture as a crucial elements for building a new kind of human being, Übermensche. For Nietzsche, one who denies his desire is the one who still can't have an affirmation on himself. In that line of thought, Nietzsche analyses the mechanism of guiltiness or consciousness. Nietzsche affirms that we need a new way of seeing the morality given to us, that of the act of re-thinking on the morality itself for oneself, the act of reasoning over the given reason, the act of philosophizing the things given to us. And that's what Nietzsche calls the ‘recent form of morality.'